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BRK inhibitor P21d
CAS No. 1338249-87-8
BRK inhibitor P21d( —— )
Catalog No. M11355 CAS No. 1338249-87-8
BRK inhibitor P21d is a potent, selective, cell permeable inhibitor of breast tumor kinase (Brk, PTK6) with IC50 of 30 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameBRK inhibitor P21d
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NoteResearch use only, not for human use.
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Brief DescriptionBRK inhibitor P21d is a potent, selective, cell permeable inhibitor of breast tumor kinase (Brk, PTK6) with IC50 of 30 nM.
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DescriptionBRK inhibitor P21d is a potent, selective, cell permeable inhibitor of breast tumor kinase (Brk, PTK6) with IC50 of 30 nM, shows no inhibitory activity against Aurora B and Lck (IC50>20 uM); exhibits potent cellular activity with p-SAM68 IC50 of 52 nM, downregulates SNAIL protein and restores E-cadherin expression in TNBC cells; suppresses migration of MDA-MB-231 and MMTV-myc cells, sensitizes TNBC cells to anoikis and suppresses metastasis formation.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayTyrosine Kinase
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TargetBreast Tumor Kinase
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RecptorBreast Tumor Kinase
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Research Area——
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Indication——
Chemical Information
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CAS Number1338249-87-8
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Formula Weight447.474
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Molecular FormulaC23H22FN7O2
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name(4-((6-cyclopropyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl)amino)-3-fluorophenyl)(morpholino)methanone
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Zeng H, et al. Bioorg Med Chem Lett. 2011 Oct 1;21(19):5870-5.
2. Ito K, et al. Cancer Res. 2016 Aug 1;76(15):4406-17.
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